Article

Therapeutic targeting of fibrin–microglia interactions ameliorates Alzheimer’s disease-related hyperexcitability and brain network dysfunction

2026-05-06

Abstract excerpt

<h4>SUMMARY</h4> Brain network dysfunction—including hyperexcitability, altered oscillations, and sleep disruption—is prominent in Alzheimer’s disease (AD), but the contribution of vascular-neuroimmune processes to these alterations remains unclear. Here, we blocked the pro-inflammatory interaction of the blood protein fibrin with microglia using genetic (Fgg γ390–396A mice) and antibody-based (5B8 and THN392) s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0468e1df-f6c8-5c19-8532-c66403e596c4
DOI: 10.64898/2026.05.01.722324

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest

Therapeutic targeting of fibrin–microglia interactions ameliorates Alzheimer’s disease-related hyperexcitability and brain network dysfunctionDOI 10.64898/2026.05.01.722324Read

Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome and decision-making by blocking fibrin in a model of Alzheimer’s diseaseSemantic proximity Read

A proteomic signature of vascular dysfunction linked to tauopathy and degeneration in the aging brainSemantic proximity Read

Relationship between topological efficiency of white matter structural connectome and plasma biomarkers across the Alzheimer's disease continuumSemantic proximity Read

Anti-amyloid immunotherapy drives APOE4 specific increases in glial reactivity, perivascular immune activation, and ARIA-like eventsSemantic proximity Read

Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer’s diseaseSemantic proximity Read

The APOE ɛ4/ɛ4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients.Semantic proximity Read

Revealing the combined roles of Aβ and tau in Alzheimer’s disease via a pathophysiological activity decoderSemantic proximity Read

Amyloid and Tau Pathology are Associated with Cerebral Blood Flow in a Mixed Sample of Nondemented Older Adults with and without Vascular Risk Factors for Alzheimer’s DiseaseSemantic proximity Read

Non-viral vasculogenic reprogramming restores cognition and mitigates pathology in Alzheimer’s diseaseSemantic proximity Read

Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillationsSemantic proximity Read

Differences in Multimodal EEG and Clinical Correlations Between Alzheimer’s Disease and Frontotemporal DementiaSemantic proximity Read