Back to search

Article

Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome and decision-making by blocking fibrin in a model of Alzheimer’s disease

2026-05-07

Abstract excerpt

<h4>Summary</h4> Cerebrovascular pathology and neuronal network dysfunction are early features of Alzheimer’s disease (AD) associated with neuroinflammation and cognitive decline, but the vascular and immune triggers of neuronal hyperactivity remain largely unknown. Here, we show that the blood coagulation protein fibrin disrupts microglia-neuron interactions, promoting neuronal hyperactivity in an AD mouse model...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9e1e09b1-8fda-54d4-8446-5cc7a989303f
DOI
10.64898/2026.05.01.722077
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome and decision-making by blocking fibrin in a model of Alzheimer’s diseaseDOI 10.64898/2026.05.01.722077
Therapeutic targeting of fibrin–microglia interactions ameliorates Alzheimer’s disease-related hyperexcitability and brain network dysfunctionSemantic proximity
Reconfiguration of neuronal subpopulation associated with disease-associated microglia in human Alzheimer’s disease brainSemantic proximity
A Spatial Risk Model Reveals a 25 μm Transcriptomic Event Horizon for Plaque-Associated Myeloid Activation in Alzheimer’s DiseaseSemantic proximity
Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemiaSemantic proximity
Amplified Microglial Dysfunction and Brain Lesions in Mouse Models for Comorbidity of Chronic Stress and Intracerebral HypoperfusionSemantic proximity
Amyloid beta peptides (Aβ) from Alzheimer’s disease neuronal secretome induce endothelial activation in a human cerebral microvessel modelSemantic proximity
Cross-tissue omics-guided drug repurposing triangulates novel targetable mechanisms for Alzheimer’s disease and candidate genetic biomarkers for treatment stratificationSemantic proximity
Microglia-Associated Neuroinflammation in Alzheimer’s DiseaseSemantic proximity
Select a neighboring publication to make it the new centre.