Article

Inhibition of CDC20 suppresses the development and progression of mantle cell lymphoma through PI3K/AKT pathway

2025-07-28

Abstract excerpt

<title>Abstract</title> <p>Cell division cycle 20 homologue (CDC20), a key regulator of mitosis, is frequently overexpressed in cancers and linked to tumor progression. However, its role in mantle cell lymphoma (MCL) remains unclear. This study explored the functional significance of CDC20 in MCL and its underlying mechanisms. CDC20 expression was analyzed in peripheral blood mononuclear cells (PBMCs), bone marro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0442a5eb-23e0-5a85-ac82-0d4ec26e4357
DOI: 10.21203/rs.3.rs-7114313/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of CDC20 suppresses the development and progression of mantle cell lymphoma through PI3K/AKT pathwayDOI 10.21203/rs.3.rs-7114313/v1Read

CDC20 in and out of mitosis: a prognostic factor and therapeutic target in hematological malignanciesSemantic proximity Read

MDM2-P53 Signaling Pathway-Mediated Upregulation of CDC20 Promotes Progression of Human Diffuse Large B-Cell LymphomaSemantic proximity Read

Pathogenesis of Mantle-Cell Lymphoma: All Oncogenic Roads Lead to Dysregulation of Cell Cycle and DNA Damage Response PathwaysSemantic proximity Read

Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic eraSemantic proximity Read

Targeting CDK4/6 in mantle cell lymphomaSemantic proximity Read

The molecular pathogenesis of mantle cell lymphoma.Semantic proximity Read

Molecular pathogenesis of mantle cell lymphomaSemantic proximity Read

NOTCH Signaling in Mantle Cell Lymphoma: Biological and Clinical Implications.Semantic proximity Read

CDC6, a key replication licensing factor, is overexpressed and confers poor prognosis in diffuse large B-cell lymphomaSemantic proximity Read

Mantle cell lymphoma: report of the 2010 Mantle Cell Lymphoma Consortium WorkshopSemantic proximity Read

Mucin 20 modulates proteasome capacity through c‐Met signalling to increase carfilzomib sensitivity in mantle cell lymphomaSemantic proximity Read

Prognostic and Therapeutic Implications of Cell Division Cycle 20 Homolog in Breast CancerSemantic proximity Read