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Targeting CDK4/6 in mantle cell lymphoma

1 Mar 2020

Abstract excerpt

Targeting the cell cycle represents a rational approach to mantle cell lymphoma (MCL) therapy, as aberrant expression of cyclin D1 and dysregulation of CDK4 underlie cell cycle progression and proliferation of MCL cells. Although cell cycle cancer therapy was historically ineffective due to a lack of selective and effective drugs, this landscape changed with the advent of selective and potent small-molecule oral...

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PMID: 32783046
DOI: 10.21037/aol.2019.12.01

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