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Article

NOTCH Signaling in Mantle Cell Lymphoma: Biological and Clinical Implications.

International journal of molecular sciences - 17 Jun 2023

Deshotels Leigh, Safa Firas M, Saba Nakhle S

Abstract excerpt

Despite major progress in mantle cell lymphoma (MCL) therapeutics, MCL remains a deadly disease with a median survival not exceeding four years. No single driver genetic lesion has been described to solely give rise to MCL. The hallmark translocation t(11;14)(q13;q32) requires additional genetic alterations for the malignant transformation. A short list of recurrently mutated genes including ATM, CCND1, UBR5,...

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Topics

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Share to Cancer-related gene regulation
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Share to Lymphoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, Mantle-Cell

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Share to Translocation, Genetic

Share to Ubiquitin and proteasome pathways

Source

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Identifiers

PMID: 37373427
DOI: 10.3390/ijms241210280
PMCID: PMC10299455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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