Article

Pluripotent stem cell-derived siTNK cells attack tumors via a synthetic CD8-CD28-TCR complex

2025-07-12

Abstract excerpt

<h4>SUMMARY</h4> Tumor-associated antigen-specific T cell receptor (TCR)-engineered T cells offer a promising strategy for cancer therapy. Natural killer (NK) cells exhibit broad anti-tumor activity with low side effects but lack the capacity to recognize intracellular antigens. Here, we found that the human pluripotent stem cell (hPSC)-derived iNK cells, unlike tissue-isolated NK cells, expressed all four CD3 su...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 043c7578-eaf0-5ac6-8f67-8c1c9492b622
DOI: 10.1101/2025.07.11.663392

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pluripotent stem cell-derived siTNK cells attack tumors via a synthetic CD8-CD28-TCR complexDOI 10.1101/2025.07.11.663392Read

Generation of dual-attribute iTNK cells from hPSCs for cancer immunotherapySemantic proximity Read

Engineered CRO-CD7 CAR-NK cells derived from pluripotent stem cells avoid fratricide and efficiently suppress human T-cell malignanciesSemantic proximity Read

Engineered CRO-CD7 CAR-NK cells derived from pluripotent stem cells avoid fratricide and efficiently suppress human T-cell malignanciesSemantic proximity Read

From induced pluripotent stem cell (iPSC) to universal immune cells: literature review of advances in a new generation of tumor therapiesSemantic proximity Read

Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy.Semantic proximity Read

Generation and clinical potential of functional T lymphocytes from gene-edited pluripotent stem cellsSemantic proximity Read

Multiplexed iPSC platform for advanced NK cell immunotherapiesSemantic proximity Read

Induced Pluripotent Stem Cell-Based Cancer Immunotherapy: Strategies and PerspectivesSemantic proximity Read

Efficient Generation of Functional TCRαβ <sup>+</sup> Cytotoxic T Cells from hiPSCs via Small-Molecule ModulationSemantic proximity Read

Derivation of mimetic γδ T cells endowed with cancer recognition receptors from reprogrammed γδ T cellSemantic proximity Read

Concise Review: Human Pluripotent Stem Cells to Produce Cell-Based Cancer ImmunotherapySemantic proximity Read

Genetically stable multi-gene edited iPSCs-derived NK cells for enhanced cancer immunotherapySemantic proximity Read