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From induced pluripotent stem cell (iPSC) to universal immune cells: literature review of advances in a new generation of tumor therapies

1 Apr 2025

Abstract excerpt

Background and Objective: Tumor therapy is still a tough clinical challenge, and cancer immunotherapy has drawn increasing attention. T cells and natural killer (NK) cells play crucial roles in the immune response. Induced pluripotent stem cell (iPSC) technology opens up a new way to produce functionally improved universal iPSC-derived chimeric antigen receptor (CAR) T (CAR-iT) and iPSC-derived CAR-NK (CAR-iNK)...

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PMID: 40386273
DOI: 10.21037/tcr-24-1087

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