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Article

Genetically stable multi-gene edited iPSCs-derived NK cells for enhanced cancer immunotherapy

23 Sept 2024

Abstract excerpt

Chimeric antigen receptor (CAR)-T cell treatment is an innovative drug with excellent therapeutic effects against B cell blood cancer. However, multiple side effects and ultra-high treatment costs must be overcome. Off-the-shelf CAR natural killer (NK) cells can be a good alternative to patient-specific CAR-T cells. The purpose of this study was to combine cellular reprogramming, gene editing, and differentiation...

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PMID: 40092294
DOI: 10.1016/j.omton.2024.200885

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