Engineered CRO-CD7 CAR-NK cells derived from pluripotent stem cells avoid fratricide and efficiently suppress human T-cell malignancies

Abstract excerpt

<h4>Background</h4> T cell malignancies are highly aggressive hematological tumors with limited effective treatment options. CAR-NK cell therapy targeting CD7 has emerged as a promising approach for treating T-cell malignancies. However, conventional CAR-NK cell therapy faces the challenges of cell fratricide due to CD7 expression on both malignant cells and normal NK cells. Additionally, engineering CARs into hu...

Topics

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• CAR-T cell therapy research
• CRISPR and Genetic Engineering
• Immune Cell Function and Interaction
• Nanowire Synthesis and Applications
• Pluripotent Stem Cells Research
• RNA Interference and Gene Delivery
• Viral Infectious Diseases and Gene Expression in Insects
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

d6ad749d-2a48-53a8-99fc-9908b2b3b336

DOI

10.1101/2025.01.23.634617