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Generation and clinical potential of functional T lymphocytes from gene-edited pluripotent stem cells

14 May 2022

Abstract excerpt

Engineered T cells have been shown to be highly effective in cancer immunotherapy, although T cell exhaustion presents a challenge for their long-term function. Additional T-cell sources must be exploited to broaden the application of engineered T cells for immune defense and reconstitution. Unlimited sources of pluripotent stem cells (PSCs) have provided a potential opportunity to generate precise-engineered...

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PMID: 35568954
DOI: 10.1186/s40164-022-00285-y

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