Article

High immune receptor clonality in melanoma-draining lymph nodes associates with immune dysfunction and poor survival

2026-06-10

Abstract excerpt

Tumor-draining lymph nodes (tdLNs) are critical hubs of anti-tumor immunity but are also vulnerable to tumor-mediated immunosuppression. We analyzed T cell and B cell receptor (TCR/BCR) repertoires and transcriptomes from sentinel and non-sentinel lymph nodes of patients with melanoma from a historical pre–immune checkpoint inhibitor cohort (1994-2002) and an independent contemporary validation cohort (2022-2024)....

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Literature Corpus work: 0412738c-e093-55b1-a1e4-b690c39e38f1
DOI: 10.64898/2026.06.09.729531

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