Article
β-Catenin-mediated immune evasion pathway frequently operates in primary cutaneous melanomas.
The Journal of clinical investigation - 1 May 2018
Nsengimana Jérémie, Laye Jon, Filia Anastasia, O'Shea Sally, Muralidhar Sathya, Poźniak Joanna, Droop Alastair, Chan May, Walker Christy, Parkinson Louise, Gascoyne Joanne, Mell Tracey, Polso Minttu, Jewell Rosalyn, Randerson-Moor Juliette, Cook Graham P, Bishop D Timothy, Newton-Bishop Julia
Abstract excerpt
Immunotherapy prolongs survival in only a subset of melanoma patients, highlighting the need to better understand the driver tumor microenvironment. We conducted bioinformatic analyses of 703 transcriptomes to probe the immune landscape of primary cutaneous melanomas in a population-ascertained cohort. We identified and validated 6 immunologically distinct subgroups, with the largest having the lowest immune...
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