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Single-cell transcriptomics of melanoma sentinel lymph nodes identifies immune cell signatures associated with metastasis

6 Mar 2025

Abstract excerpt

The sentinel lymph node (SLN) is the first lymph node encountered by a metastatic cancer cell and serves as a predictor of poor prognosis, as cases with clinically occult SLN metastases are classified as stage III with elevated rates of recurrence and diminished overall survival. However, the dynamics of immune infiltrates in SLNs remain poorly characterized. Here, using an unbiased cellular indexing of...

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PMID: 40048259
DOI: 10.1172/jci.insight.183080

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