Article

Unique Transcriptional Signatures Correlate with Behavioral and Psychological Symptom Domains in Alzheimer’s Disease

2023-01-11

Abstract excerpt

<title>Abstract</title> <p>Despite the significant burden, cost, and worse prognosis of Alzheimer’s Disease (AD) with Behavioral and Psychological Symptoms of Dementia (BPSD), little is known about the molecular causes of these symptoms. Using antemortem assessments of BPSD in AD, we demonstrate that individual BPSD can be grouped into 4 domain factors in our sample: Affective, Apathy, Agitation, and Psychosis. T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 03d7b502-2396-5928-90aa-77430efb1cac
DOI: 10.21203/rs.3.rs-2444391/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unique Transcriptional Signatures Correlate with Behavioral and Psychological Symptom Domains in Alzheimer’s DiseaseDOI 10.21203/rs.3.rs-2444391/v1Read

Unique transcriptional signatures correlate with behavioral and psychological symptom domains in Alzheimer’s diseaseSemantic proximity Read

Association of RDoC dimensions with post-mortem brain transcriptional profiles in Alzheimer’s DiseaseSemantic proximity Read

Behavioral and psychological symptoms of dementia: insights from a multivariate and network-based brain proteome-wide studySemantic proximity Read

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease.Semantic proximity Read

Decoding cell-type-specific alterations in Alzheimer’s disease through scRNA-seq and network analysisSemantic proximity Read

Comparative cortical transcriptomic profiling of Alzheimer’s disease, vascular dementia and mixed dementiaSemantic proximity Read

Transcriptional Alterations Related to Neuropathology and Clinical Manifestation of Alzheimer’s DiseaseSemantic proximity Read

Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disordersSemantic proximity Read

Identification of conserved proteomic networks in neurodegenerative dementiaSemantic proximity Read

Integrated Analysis of Cortex Single-Cell Transcriptome and Serum Proteome Reveals the Novel Biomarkers in Alzheimer’s DiseaseSemantic proximity Read

Integrated Bioinformatics and Ensemble Learning Reveal Diagnostic Modeling and Drug Discovery in Alzheimer’s DiseaseSemantic proximity Read

Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disordersSemantic proximity Read