Article

Pancreatic cancer extracellular vesicles carry a time-of-day-regulated miRNA cargo that disrupts the skeletal muscle clock and bioenergetics

2026-05-04

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic ductal adenocarcinoma (PDAC) carries a dismal prognosis, aggravated by cachexia, a systemic wasting syndrome whose molecular mediators remain incompletely defined. Circadian disruption is a further hallmark of PDAC, yet a shared mechanistic basis between these two features has not been established. Here we show that the PDAC secretome, and the small extracellular vesicles (sEVs) it ca...

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Literature Corpus work: 03cc29bf-13db-5ced-b670-52c3d863afd4
DOI: 10.64898/2026.05.03.722338

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