Article

Improving stem cell-derived pancreatic islets using single-cell multiome-inferred regulomes

2022-09-26

Abstract excerpt

Pancreatic islet cells derived from human pluripotent stem cells hold great promise for modeling and treating diabetes. Differences between stem cell-derived and primary islets remain, but molecular insights to inform improvements are limited. Here, we acquire single-cell transcriptomes and accessible chromatin profiles during in vitro islet differentiation and pancreas from childhood and adult donors for compari...

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Literature Corpus work: ed2e96d5-5ba1-5860-a1d0-ce7cab559f2f
DOI: 10.1101/2022.09.25.509355

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