Article

Increasing phagocytosis of microglia through targeting CD33 with liposomes displaying glycan ligands

2021-05-09

Abstract excerpt

CD33 is an immunomodulatory receptor expressed on microglia and genetically linked to Alzheimer’s disease (AD) susceptibility. While antibodies targeting CD33 have entered clinical trials to treat neurodegeneration, it is unknown whether the glycan-binding properties of CD33 can be exploited to modulate microglia. Here, we use liposomes that multivalently display glycan ligands of CD33 (CD33L liposomes) to engage...

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Literature Corpus work: e2c9ddb6-d63b-57fb-913e-1e7b37247b26
DOI: 10.1101/2021.05.08.443135

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