Article

Generation of Murine Carcinoma Models with Functional Heterologous HER1 and/or HER2 Receptors for In Vivo Study of Specific Therapies

2025-02-20

Abstract excerpt

HER1 and HER2 (human epidermal growth factor receptors 1-2) are essential proteins for cellular physiology. Dysregulation of these receptors plays a key role in tumorigenesis. This turns both oncogenic receptors into targets for antitumor therapies, which currently include passive and active immunotherapy strategies, such as monoclonal antibodies and therapeutic vaccines. In this context, preclinical studies in im...

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Literature Corpus work: 03af7c8c-289e-55d7-9bf3-b9d2442f25aa
DOI: 10.20944/preprints202502.1582.v1

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