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Molecular biology of human epidermal receptors, signaling pathways and targeted therapy against cancers: new evidences and old challenges

2017-01-01

Abstract excerpt

Human epidermal receptors (HER1/2/3/4) belong to the class of receptor-type tyrosine kinases. After binding a ligand, dimerization, it will ocurr activation of intracellular kinases after two-dimensional and cytoplasmic tail reciprocal transphosphorylation. This transphosphorylation recruits signaling pathways such as Ras/Raf/MEK/Erk1-2, PI3-K/AKT and JAK/STAT, which can affect the cell cycle, cytoskeleton reorgan...

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Identifiers and source

Literature Corpus work
9d246a4e-0cf7-5fee-9d2f-268ebcef9bd5
DOI
10.1590/s2175-97902017000216076
Open publication

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Molecular biology of human epidermal receptors, signaling pathways and targeted therapy against cancers: new evidences and old challengesDOI 10.1590/s2175-97902017000216076
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