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Molecular Pathways and Mechanisms of HER2 in Cancer Therapy

27 Dec 2022

Abstract excerpt

The oncogene ERBB2 encoding the receptor tyrosine-protein kinase erbB-2 (HER2) is frequently overexpressed or amplified and occasionally mutated in a variety of human cancers. The early discovery of this oncogene, its established oncogenic relevance in diverse cancers, its substantial expression on the surface of cancer cells, and its druggable catalytic activity have made it one of the most pursued targets in...

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PMID: 36574481
DOI: 10.1158/1078-0432.ccr-22-0283

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