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Article

Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family

30 Oct 2008

Abstract excerpt

The human EGFR (HER) family is essential for communication between many epithelial cancer cell types and the tumor microenvironment. Therapeutics targeting the HER family have demonstrated clinical success in the treatment of diverse epithelial cancers. Here we propose that the success of HER family-targeted monoclonal antibodies in cancer results from their ability to interfere with HER family consolidation of...

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PMID: 18982164
DOI: 10.1172/jci36049

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