Article

Thermodynamic and kinetic design principles for protein aggregation inhibitors

2020-02-24

Abstract excerpt

Understanding the mechanism of action of compounds capable of inhibiting protein aggregation is critical to the development of potential ther-apeutics against protein misfolding diseases. A fundamental challenge for progress is the range of possible target species and the disparate timescales involved, since the aggregating proteins are simultaneously the reactants, products, intermediates and catalysts of the rea...

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Literature Corpus work: 037d55ed-f021-5e6d-8749-4828d03642ae
DOI: 10.1101/2020.02.22.960716

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