Article

Structural hormesis in protein aggregation: A minimal mechanistic model

2025-10-08

Abstract excerpt

Protein aggregation underlies the pathogenesis of many neurodegenerative diseases, and inhibitors are often assumed to elicit monotonic dose–responses. We ask whether simple aggregation pathways can intrinsically generate hormesis—a biphasic profile with low–dose stimulation and high–dose inhibition. We formulate a minimal mechanistic model in which a single inhibitor interacts sequentially with pathway intermedi...

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Identifiers and source

Literature Corpus work: 631bb64e-99d8-564d-8408-e0c348bccf88
DOI: 10.1101/2025.10.07.681066

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