To What Extent is Anfinsen’s Thermodynamic Hypothesis Consistent With the Formation and Polymorphism of Amyloid Fibrils?

Abstract excerpt

For half a century, Anfinsen's Thermodynamic Hypothesis has been considered the central pillar of protein science. In Anfinsen's words, this hypothesis holds that "…the three-dimensional structure of a native protein in its normal physiological milieu…is the one in which the Gibbs free energy of the whole system is lowest; that is, that the native conformation is determined by the totality of interatomic...