Article
Solubis: optimize your protein.
Bioinformatics (Oxford, England) - 1 Aug 2015
De Baets Greet, Van Durme Joost, van der Kant Rob, Schymkowitz Joost, Rousseau Frederic
Abstract excerpt
MOTIVATION: Protein aggregation is associated with a number of protein misfolding diseases and is a major concern for therapeutic proteins. Aggregation is caused by the presence of aggregation-prone regions (APRs) in the amino acid sequence of the protein. The lower the aggregation propensity of APRs and the better they are protected by native interactions within the folded structure of the protein, the more...
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