Article

Maturation-dependent complement production and C3 processing in human retinal pigment epithelium cells

2025-02-05

Abstract excerpt

Induced pluripotent stem cell-derived retinal pigment epithelial (iPSC-RPE) cells, closely resembling healthy RPE, offer valuable insights for retinal disease modelling. This study evaluates immature and mature phenotypes of iPSC-RPE and ARPE-19 cells, comparing RPE characteristics, cell-associated complement profiles, and TGF-β1-mediated stress responses across transcript expression, secretion, and protein levels...

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Literature Corpus work: 037289ac-e81f-58a8-a553-87d96a63da8a
DOI: 10.1101/2025.02.05.636432

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