Article

Redistribution of sidechain-sidechain interactions govern ligand-specific binding affinity changes in missense Shank1 PDZ variants

2025-07-04

Abstract excerpt

Shank proteins represent a family of abundant scaffolds in the postsynaptic density. Their dysfunctions had been identified as possible causes behind autism spectrum disorders and various types of cancer. The remarkably promiscuous PDZ domain of the Shank family is highly conserved through isoforms, and contains a unique dynamic segment, the β2-β3 loop, located close to the binding site. We used the Shank1 PDZ as...

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Literature Corpus work: e69308cb-8ea9-5c38-992c-2955f7197c8e
DOI: 10.1101/2025.07.03.662971

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