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Article

Structural basis for the nucleotide-dependent dimerization of the large G protein atlastin-1/SPG3A.

Proceedings of the National Academy of Sciences of the United States of America - 8 Feb 2011

Byrnes Laura J, Sondermann Holger

Abstract excerpt

The large GTPase atlastin belongs to the dynamin superfamily that has been widely implicated in facilitating membrane tubulation, fission, and in select cases, fusion. Mutations spread across atlastin isoform 1 (atlastin-1) have been identified in patients suffering from hereditary spastic paraplegia (HSP), a neurodegenerative disorder affecting motor neuron function in the lower extremities. On a molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21220294
DOI: 10.1073/pnas.1012792108
PMCID: PMC3038741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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