Receptor protein tyrosine phosphatases and cancer: new insights from structural biology.

doi:10.4161/cam.21242

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Article

Receptor protein tyrosine phosphatases and cancer: new insights from structural biology.

Cell adhesion & migration - 1 Jan 2000

Nikolaienko Roman M, Agyekum Boadi, Bouyain Samuel

Abstract excerpt

There is general agreement that many cancers are associated with aberrant phosphotyrosine signaling, which can be caused by the inappropriate activities of tyrosine kinases or tyrosine phosphatases. Furthermore, incorrect activation of signaling pathways has been often linked to changes in adhesion events mediated by cell surface receptors. Among these receptors, receptor protein tyrosine phosphatases (RPTPs)...

Topics

Animals
Cell Communication
Gene Expression
Humans
Models, Molecular
Mutation
Neoplasms
Protein Interaction Domains and Motifs
Protein Structure, Quaternary
Receptor-Like Protein Tyrosine Phosphatases

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Identifiers

PMID: 22796942
DOI: 10.4161/cam.21242
PMCID: PMC3478258

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