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Article

Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes.

Cancer research - 2 Jan 2025

Kuett Laura, Bollhagen Alina, Tietscher Sandra, Sobottka Bettina, Eling Nils, Varga Zsuzsanna, Moch Holger, de Souza Natalie, Bodenmiller Bernd

Abstract excerpt

Breast cancer is the most commonly diagnosed cancer in women, with distant metastasis being the main cause of breast cancer-related deaths. Elucidating the changes in the tumor and immune ecosystems that are associated with metastatic disease is essential to improve understanding and ultimately treatment of metastasis. Here, we developed an in-depth, spatially resolved single-cell atlas of the phenotypic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39437149
DOI: 10.1158/0008-5472.CAN-24-1211
PMCID: PMC11694063

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