Article
Evidence of Polygenic Adaptation in Sardinia at Height-Associated Loci Ascertained from the Biobank Japan.
American journal of human genetics - 2 Jul 2020
Chen Minhui, Sidore Carlo, Akiyama Masato, Ishigaki Kazuyoshi, Kamatani Yoichiro, Schlessinger David, Cucca Francesco, Okada Yukinori, Chiang Charleston W K
Abstract excerpt
Adult height is one of the earliest putative examples of polygenic adaptation in humans. However, this conclusion was recently challenged because residual uncorrected stratification from large-scale consortium studies was considered responsible for the previously noted genetic difference. It thus remains an open question whether height loci exhibit signals of polygenic adaptation in any human population. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.