Article
IBEX: A versatile multiplex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues.
Proceedings of the National Academy of Sciences of the United States of America - 29 Dec 2020
Radtke Andrea J, Kandov Evelyn, Lowekamp Bradley, Speranza Emily, Chu Colin J, Gola Anita, Thakur Nishant, Shih Rochelle, Yao Li, Yaniv Ziv Rafael, Beuschel Rebecca T, Kabat Juraj, Croteau Joshua, Davis Jeremy, Hernandez Jonathan M, Germain Ronald N
Abstract excerpt
The diverse composition of mammalian tissues poses challenges for understanding the cell-cell interactions required for organ homeostasis and how spatial relationships are perturbed during disease. Existing methods such as single-cell genomics, lacking a spatial context, and traditional immunofluorescence, capturing only two to six molecular features, cannot resolve these issues. Imaging technologies have been...
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