Article

To mock or not: a comprehensive comparison of mock IP and DNA input for ChIP-seq

2019-12-18

Abstract excerpt

<h4>ABSTRACT</h4> Chromatin immunoprecipitation (IP) followed by sequencing (ChIP-seq) is the gold standard to detect genome-wide DNA-protein binding. The binding sites of transcription factors facilitate many biological studies. Of emerging concern is the abundance of spurious sites in ChIP-seq, which are mainly caused by uneven genomic sonication and nonspecific interactions between chromatin and antibody. A “m...

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Literature Corpus work: 03264303-554e-54f9-90ae-80c48c053da8
DOI: 10.1101/2019.12.17.880013

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