Article
PeakSeq enables systematic scoring of ChIP-seq experiments relative to controls.
Nature biotechnology - 1 Jan 2009
Rozowsky Joel, Euskirchen Ghia, Auerbach Raymond K, Zhang Zhengdong D, Gibson Theodore, Bjornson Robert, Carriero Nicholas, Snyder Michael, Gerstein Mark B
Abstract excerpt
Chromatin immunoprecipitation (ChIP) followed by tag sequencing (ChIP-seq) using high-throughput next-generation instrumentation is fast, replacing chromatin immunoprecipitation followed by genome tiling array analysis (ChIP-chip) as the preferred approach for mapping of sites of transcription-factor binding and chromatin modification. Using two deeply sequenced data sets for human RNA polymerase II and STAT1,...
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