Article

Loss of expression of the E3 ligase and tumour suppressor FBW7 attenuates vitamin D signaling

2026-04-20

Abstract excerpt

<title>Abstract</title> <p> Hormonal 1,25-dihydroxyvitamin D (1,25D) and its analogues signal through the nuclear vitamin D receptor (VDR). While numerous preclinical studies have provided evidence for antiproliferative and antitumour activities of 1,25D (analogues), such compounds have failed in clinical trials because of acquired tumour resistance. We previously found that the E3 ligase FBW7 interacts with the...

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Literature Corpus work: 02f4f27d-7114-5353-bc64-568e1d448ccc
DOI: 10.21203/rs.3.rs-9181172/v1

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Loss of expression of the E3 ligase and tumour suppressor FBW7 attenuates vitamin D signalingDOI 10.21203/rs.3.rs-9181172/v1Read

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