Article
Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations.
eLife - 28 Feb 2022
Thirimanne H Nayanga, Wu Feinan, Janssens Derek H, Swanger Jherek, Diab Ahmed, Feldman Heather M, Amezquita Robert A, Gottardo Raphael, Paddison Patrick J, Henikoff Steven, Clurman Bruce E
Abstract excerpt
The Fbw7 ubiquitin ligase targets many proteins for proteasomal degradation, which include oncogenic transcription factors (TFs) (e.g., c-Myc, c-Jun, and Notch). Fbw7 is a tumor suppressor and tumors often contain mutations in FBXW7, the gene that encodes Fbw7. The complexity of its substrate network has obscured the mechanisms of Fbw7-associated tumorigenesis, yet this understanding is needed for developing...
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