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Article

Long read sequencing reveals poxvirus evolution through rapid homogenization of gene arrays.

eLife - 29 Aug 2018

Sasani Thomas A, Cone Kelsey R, Quinlan Aaron R, Elde Nels C

Abstract excerpt

Poxvirus adaptation can involve combinations of recombination-driven gene copy number variation and beneficial single nucleotide variants (SNVs) at the same loci. How these distinct mechanisms of genetic diversification might simultaneously facilitate adaptation to host immune defenses is unknown. We performed experimental evolution with vaccinia virus populations harboring a SNV in a gene actively undergoing...

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Share to Adaptation, Physiological
Share to DNA Copy Number Variations
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Conversion

Share to High-Throughput Nucleotide Sequencing

Share to Polymorphism, Single Nucleotide

Share to Recombination, Genetic

Share to Vaccinia virus

Source

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Identifiers

PMID: 30156554
DOI: 10.7554/eLife.35453
PMCID: PMC6115191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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