Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants.

Vaccine - 2 Jan 2013

Bustamante Leyla Y, Bartholdson S Josefin, Crosnier Cecile, Campos Marta G, Wanaguru Madushi, Nguon Chea, Kwiatkowski Dominic P, Wright Gavin J, Rayner Julian C

Abstract excerpt

The lack of an effective licensed vaccine remains one of the most significant gaps in the portfolio of tools being developed to eliminate Plasmodium falciparum malaria. Vaccines targeting erythrocyte invasion - an essential step for both parasite development and malaria pathogenesis - have faced the particular challenge of genetic diversity. Immunity-driven balancing selection pressure on parasite invasion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Protozoan
Share to Antigens, Protozoan

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carrier Proteins

Share to Erythrocytes

Share to Malaria, Falciparum

Share to Malaria Vaccines

Share to Plasmodium falciparum

Share to Recombinant Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23146673
DOI: 10.1016/j.vaccine.2012.10.106
PMCID: PMC3538003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants.PMID 23146673Read ↗

Assessing the functional impact of PfRh5 genetic diversity on ex vivo erythrocyte invasion inhibition.Semantic proximity Read ↗

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody ClonotypeSemantic proximity Read ↗

Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against<i>P. falciparum</i>clinical isolatesSemantic proximity Read ↗

Extent and Dynamics of Polymorphism in the Malaria Vaccine Candidate Plasmodium falciparum Reticulocyte–Binding Protein Homologue-5 in Kalifabougou, MaliSemantic proximity Read ↗

Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotypeSemantic proximity Read ↗

Estimation of PfRh5-based vaccine efficacy in asymptomatic Plasmodium falciparum patients from high-endemic areas of Tanzania using genetic and antigenicity variation screening.Semantic proximity Read ↗

Genetic diversity in the Plasmodium falciparum next-generation blood stage vaccine candidate antigen PfCyRPA in SenegalSemantic proximity Read ↗

Genetic diversity in the Plasmodium falciparum next-generation blood stage vaccine candidate antigen PfCyRPA in Senegal.Semantic proximity Read ↗

The Plasmodium falciparum Rh5 invasion protein complex reveals an excess of rare variant mutations.Semantic proximity Read ↗

Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malariaSemantic proximity Read ↗

Evidence That the Erythrocyte Invasion Ligand PfRh2 is a Target of Protective Immunity against Plasmodium falciparum MalariaSemantic proximity Read ↗

Functional Analysis Reveals Geographical Variation in Inhibitory Immune Responses Against a Polymorphic Malaria Antigen.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.