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Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies

14 Jun 2017

Abstract excerpt

BACKGROUND: Plasmodium vivax is the most widespread human malaria geographically; however, no effective vaccine exists. Red blood cell invasion by the P. vivax merozoite depends on an interaction between the Duffy antigen receptor for chemokines (DARC) and region II of the parasite's Duffy-binding protein (PvDBP_RII). Naturally acquired binding-inhibitory antibodies against this interaction associate with...

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PMID: 28614791
DOI: 10.1172/jci.insight.93683

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