Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A PfRH5-Based Vaccine Is Efficacious against Heterologous Strain Blood-Stage Plasmodium falciparum Infection in Aotus Monkeys

1 Jan 2015

Abstract excerpt

Antigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only strain-specific protection has been reported by trials of such vaccines in nonhuman primates. We recently showed that P. falciparum reticulocyte binding protein homolog 5 (PfRH5), a merozoite adhesin required for erythrocyte...

Source

Identifiers

PMID: 25590760
DOI: 10.1016/j.chom.2014.11.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A PfRH5-Based Vaccine Is Efficacious against Heterologous Strain Blood-Stage Plasmodium falciparum Infection in Aotus MonkeysPMID 25590760Read ↗

Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against<i>P. falciparum</i>clinical isolatesSemantic proximity Read ↗

Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodiesSemantic proximity Read ↗

The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibodySemantic proximity Read ↗

A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants.Semantic proximity Read ↗

Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotypeSemantic proximity Read ↗

The RH5-CyRPA-Ripr Complex as a Malaria Vaccine TargetSemantic proximity Read ↗

Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malariaSemantic proximity Read ↗

Estimation of PfRh5-based vaccine efficacy in asymptomatic Plasmodium falciparum patients from high-endemic areas of Tanzania using genetic and antigenicity variation screening.Semantic proximity Read ↗

Immunogenicity of a chimeric Plasmodium falciparum merozoite surface protein vaccine in Aotus monkeysSemantic proximity Read ↗

Evidence That the Erythrocyte Invasion Ligand PfRh2 is a Target of Protective Immunity against Plasmodium falciparum MalariaSemantic proximity Read ↗

APC-Targeted DNA Vaccination Against Reticulocyte-Binding Protein Homolog 5 Induces Plasmodium falciparum-Specific Neutralizing Antibodies and T Cell ResponsesSemantic proximity Read ↗

Genetic variation among Plasmodium vivax isolates adapted to non-human primates and the implication for vaccine development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.