Article

A model of compound heterozygous, loss-of-function alleles is broadly consistent with observations from complex-disease GWAS datasets

2016-04-15

Abstract excerpt

The genetic component of complex disease risk in humans remains largely unexplained. A corollary is that the allelic spectrum of genetic variants contributing to complex disease risk is unknown. Theoretical models that relate population genetic processes to the maintenance of genetic variation for quantitative traits may suggest profitable avenues for future experimental design. Here we use forward simulation to m...

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Literature Corpus work: 7ab658ca-a757-5d55-a8d3-2cc0a9e125aa
DOI: 10.1101/048819

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