Article

Model for de novo mutation propagation depending on paternal age at conception and associated neurological disorders

2018-03-22

Abstract excerpt

This paper presents a computational model for simulating the propagation of de novo mutations and paternal age effects in populations. The model uses data for paternal de novo mutation rates depending on age and demographic data such as age distributions, birth distributions versus age, varying life expectancy, and correlations with fertility. The number of paternal de novo mutations in children increases with...

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Identifiers and source

Literature Corpus work: 112ae09e-5f82-5b52-b7ae-09b6bf4e0d14
DOI: 10.12688/f1000research.13619.1

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