Article

The predictive capacity of polygenic risk scores for disease risk is only moderately influenced by imputation panels tailored to the target population

2023-08-29

Abstract excerpt

Polygenic risk scores (PRS) predict individuals’ genetic risk of developing complex diseases. They summarize the effect of many genetic variants discovered in genome-wide association studies (GWASs). However, to date, large GWASs exist primarily for the European population and the quality of PRS prediction declines when applied to target sets of other ethnicities. A key step in using a PRS is imputation, which is...

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Literature Corpus work: 02e72ed5-1925-5b03-a069-0b0d040067cd
DOI: 10.1101/2023.08.29.23294769

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