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Article

The predictive capacity of polygenic risk scores for disease risk is only moderately influenced by imputation panels tailored to the target population.

Bioinformatics (Oxford, England) - 1 Feb 2024

Levi Hagai, Elkon Ran, Shamir Ron

Abstract excerpt

MOTIVATION: Polygenic risk scores (PRSs) predict individuals' genetic risk of developing complex diseases. They summarize the effect of many variants discovered in genome-wide association studies (GWASs). However, to date, large GWASs exist primarily for the European population and the quality of PRS prediction declines when applied to other ethnicities. Genetic profiling of individuals in the discovery set (on...

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PMID: 38265251
DOI: 10.1093/bioinformatics/btae036
PMCID: PMC10868313

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