Article

Aclarubicin disrupts RNA polymerase II progression at replication-coupled histone genes

2026-07-09

Abstract excerpt

Anthracyclines are highly effective chemotherapeutic agents that cause DNA and chromatin damage. One member of the anthracyclines, aclarubicin, has recently gained therapeutic interest due to its ability to kill cancer cells through chromatin-based mechanisms, thus avoiding the off-target effects associated with DNA damage. Despite this, the molecular mechanism of action leading to aclarubicin-induced chromatin da...

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Literature Corpus work: 02e4f1e8-11b0-57d4-abac-342ab06e0d0b
DOI: 10.64898/2026.07.08.737292

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