Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human PARP1 Facilitates Transcription through a Nucleosome and Histone Displacement by Pol II In Vitro

26 Jun 2022

Abstract excerpt

Human poly(ADP)-ribose polymerase-1 (PARP1) is a global regulator of various cellular processes, from DNA repair to gene expression. The underlying mechanism of PARP1 action during transcription remains unclear. Herein, we have studied the role of human PARP1 during transcription through nucleosomes by RNA polymerase II (Pol II) in vitro. PARP1 strongly facilitates transcription through mononucleosomes by Pol II...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35806109
DOI: 10.3390/ijms23137107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human PARP1 Facilitates Transcription through a Nucleosome and Histone Displacement by Pol II In VitroPMID 35806109Read ↗

Transcriptional Roles of PARP1 in CancerSemantic proximity Read ↗

PARP1: Liaison of Chromatin Remodeling and TranscriptionSemantic proximity Read ↗

PARP1 as an Epigenetic Modulator: Implications for the Regulation of Host-Viral DynamicsSemantic proximity Read ↗

Transcriptional regulation mechanism of PARP1 and its application in disease treatmentSemantic proximity Read ↗

The <scp>PARP</scp> family: insights into functional aspects of poly ( <scp>ADP</scp> ‐ribose) polymerase‐1 in cell growth and survivalSemantic proximity Read ↗

Beyond DNA Repair: Additional Functions of PARP-1 in CancerSemantic proximity Read ↗

Beyond PARP1: The Potential of Other Members of the Poly (ADP-Ribose) Polymerase Family in DNA Repair and Cancer TherapeuticsSemantic proximity Read ↗

PARP (Poly ADP‐ribose Polymerase) Family in Health and DiseaseSemantic proximity Read ↗

Recent Progress in Poly(ADP–Ribose) Polymerase‐1 Inhibitors for Application in CancerSemantic proximity Read ↗

PARP1 Val762Ala polymorphism reduces enzymatic activity.Semantic proximity Read ↗

Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1Semantic proximity Read ↗

Pleiotropic Cellular Functions of PARP1 in Longevity and Aging: Genome Maintenance Meets InflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.