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Article

Dysregulation of the basal RNA polymerase transcription apparatus in cancer.

Nature reviews. Cancer - 1 May 2013

Bywater Megan J, Pearson Richard B, McArthur Grant A, Hannan Ross D

Abstract excerpt

Mutations that directly affect transcription by RNA polymerases rank among the most central mediators of malignant transformation, but the frequency of new anticancer drugs that selectively target defective transcription apparatus entering the clinic has been limited. This is because targeting the large protein-protein and protein-DNA interfaces that control both generic and selective aspects of RNA polymerase...

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Identifiers

PMID: 23612459
DOI: 10.1038/nrc3496

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