Article
Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.
Molecular cell - 7 Dec 2017
Lehmann Laura C, Hewitt Graeme, Aibara Shintaro, Leitner Alexander, Marklund Emil, Maslen Sarah L, Maturi Varun, Chen Yang, van der Spoel David, Skehel J Mark, Moustakas Aristidis, Boulton Simon J, Deindl Sebastian
Abstract excerpt
Human ALC1 is an oncogene-encoded chromatin-remodeling enzyme required for DNA repair that possesses a poly(ADP-ribose) (PAR)-binding macro domain. Its engagement with PARylated PARP1 activates ALC1 at sites of DNA damage, but the underlying mechanism remains unclear. Here, we establish a dual role for the macro domain in autoinhibition of ALC1 ATPase activity and coupling to nucleosome mobilization. In the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.