Article
Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways.
Cell reports - 31 Mar 2020
Muri Jonathan, Feng Qian, Wolleb Helene, Shamshiev Abdijapar, Ebner Christian, Tortola Luigi, Broz Petr, Carreira Erick M, Kopf Manfred
Abstract excerpt
Oxidized lipids play a critical role in a variety of diseases with two faces: pro- and anti-inflammatory. The molecular mechanisms of this Janus-faced activity remain largely unknown. Here, we have identified that cyclopentenone-containing prostaglandins such as 15d-PGJ2 and structurally related oxidized phospholipid species possess a dual and opposing bioactivity in inflammation, depending on their...
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