Article

Metabolic Reprogramming and Therapeutic Vulnerabilities in the Tumor Microenvironment Revealed by Multi-scale Network Geometry

2025-11-17

Abstract excerpt

The tumor microenvironment comprises diverse cell populations that coordinate metabolic activities to sustain malignant growth, yet the systems-level organization of these interactions remains poorly understood. Here, we present an integrated framework combining single-cell transcriptomics, genome-scale metabolic modeling, and multi-scale network geometry to decode metabolic coordination in colorectal cancer. We d...

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Literature Corpus work: 02dfbfd1-ebbb-5d01-8c6a-9b9fc351dc0f
DOI: 10.1101/2025.11.16.688737

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